The demonstration turned violent after the Police fired tear gas into the agitated crowd to restore calm. In addition to the tear gas, the Police responded to the protesters with water cannons.
Although it is unknown what may have prompted the action, some protesters were seen pelting stones at the Police and their vehicles.
Earlier, there was a standoff between the Police and the protesters over the approved route for the demonstration.
This was after the Police tried to enforce the Accra High Court directive that asked the protesters to move from the Obra Spot to the Independence Square.
But the protesters had wanted to march through the Ako Adjei Interchange and make a quick stop at the Jubilee House.
The Police subsequently arrested three protesters.
The three were allegedly picked up for their involvement in the chaos that marred the demonstration.
The Police have since called for reinforcement to deal with the situation.